PlyoCare Balls
In essence, the soft covered rubbery PlyoCare balls are used for submaximal throwing work along with general arm care. Submaximal throwing meaning the throws you'll be making with these balls in the drills (Roll-ins, Walking Windups, Rocker throws, etc.) are not designed to be thrown at 100%. My concept of this is that they're meant for maximal effort throws, as opposed to max speed throws. The large differences in weights between the balls creates more movement in the constraint throws.
Leather Driveline Weighted Balls
These balls, as opposed to the Plyocare Balls, are meant for max intent throwing. These are used to build velocity by increasing arm strength and rotational speed with 100% intensity throws. The biggest jump in velocity can be seen while going through the Run n Gun throwing program. Run n Gun, as the name implies, is a full intensity sprint into a crow hop and throw to release the balls as hard as you possibly can. These throws are with the weighted leather balls and when charted over weeks of work can show significant changes in velocities. I'm including the Casey Weathers video again because he is demonstrating his amazing fluidity in the Run n Gun throws, which showcase the best use for the leather weighted balls.
-Jon